Zinc, metallothioneins, and longevity--effect of zinc supplementation: zincage study
by
Mocchegiani E, Giacconi R, Cipriano C, Costarelli L,
Muti E, Tesei S, Giuli C, Papa R, Marcellini F, Mariani E,
Rink L, Herbein G, Varin A, Fulop T, Monti D, Jajte J,
Dedoussis G, Gonos ES, Trougakos IP, Malavolta M.
Immunology Center (Section: Nutrigenomic and Immunosenescence),
Research Department, Italian National Research Center on Ageing,
Ancona, Italy.
e.mocchegiani@inrca.it
Ann N Y Acad Sci. 2007 Nov;1119:129-46. L
ABSTRACTAging is an inevitable biological process that is associated with gradual and spontaneous biochemical and physiological changes and increased susceptibility to diseases. Because nutritional factors are involved in improving immune functions, metabolic harmony, and antioxidant defense, some nutritional factors, such as zinc, may modify susceptibility to disease and promote healthy aging. In vitro (human lymphocytes exposed to endotoxins) and in vivo (old or young mice fed with low zinc dietary intake) studies revealed that zinc is important for immune efficiency (innate and adaptive), antioxidant activity (supeoxide dismutase), and cell differentiation via clusterin/apolipoprotein J. Intracellular zinc homeostasis is regulated by metallothioneins (MT) via ion release through the reduction of thiol groups in the MT molecule. This process is crucial in aging because high MT levels are not able to release zinc, resulting in low intracellular free ion availability for biological functions. Improvement in these functions occurs in the elderly after physiological zinc supplementation. In this study, the selection of elderly subjects for zinc supplementation is discussed in relation to the genetic background of MT and pro-inflammatory cytokines, such as interleukin-6, because the latter is involved both in MT-gene expression and in intracellular zinc homeostasis.Melatonin
Resveratrol
Caloric restriction
Intermittent fasting
Antiaging medicine?
Antiaging treatments
Mitochondrial enzymes
Antagonistic pleiotropy
Caloric restriction mimetics
Cryonics/negligible senescence
Lifespan-extending interventions
CR/age-related oxidative damage
Does resveratrol enhance longevity?
Resveratrol and vertebrate lifespan (PDF)
Refs
and further readingHOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family
